Backround / Introduction
 
In the late stage, degenerative age-related alterations can lead to destruction and loss of function in the affected tissue structures and can be accompanied by developmental disruptions, overload and traumatic injuries. The processes underlying these complications are complex and to date poorly understood. The development of a causal therapy is therefore very difficult.
 
Currently available drug-based therapies have a purely symptomatic effect and present numerous adverse reactions. More recent therapies, involving substances produced from the body’s own blood, are virtually free of side effects. However, their tissue regeneration potential is limited. Furthermore, proteins which can facilitate tissue destruction, such as TNF alpha, are produced in high concentrations.